HGNC (HUGO Gene Nomenclature Committee)
rest.genenames.org
The authoritative naming registry for human genes: every approved gene symbol and name, the symbols it replaced, and the cross-references that tie it to Entrez, Ensembl, UniProt, RefSeq, OMIM and the mouse and rat databases.
GET /v1/data/hgnc/gene-by-alias-name1Request
An unofficial name recorded for a gene. Wrap a multi-word name in double quotes, for example "Li-Fraumeni syndrome".
curl "https://api.fastcrw.com/v1/data/hgnc/gene-by-alias-name?alias_name=%22Li-Fraumeni+syndrome%22" \ -H "Authorization: Bearer $FASTCRW_API_KEY"
2Response example
A sample shape. Press Run to see live data from HGNC (HUGO Gene Nomenclature Committee).
{
"responseHeader": {
"status": 0,
"QTime": 1
},
"response": {
"numFound": 1,
"start": 0,
"numFoundExact": true,
"docs": [
{
"symbol": "TP53",
"locus_group": "protein-coding gene",
"orphanet": 120204,
"gene_group_id": [
4068
],
"vega_id": "OTTHUMG00000162125",
"ensembl_gene_id": "ENSG00000141510",
"ccds_id": [
"CCDS11118",
"CCDS45605",
"CCDS45606",
"CCDS73963",
"CCDS73964",
"CCDS73965",
"CCDS73966",
"CCDS73967",
"CCDS73968",
"CCDS73969",
"… 2 more items"
],
"gene_group": [
"p53 transcription factor family"
],
"ena": [
"AF307851"
],
"mgd_id": [
"MGI:98834"
],
"date_approved_reserved": "1986-01-01T00:00:00Z",
"date_name_changed": "2008-01-16T00:00:00Z",
"entrez_id": "7157",
"date_modified": "2023-01-20T00:00:00Z",
"alias_name": [
"Li-Fraumeni syndrome"
],
"locus_type": "gene with protein product",
"pubmed_id": [
6396087,
3456488,
2047879
],
"refseq_accession": [
"NM_000546"
],
"mane_select": [
"ENST00000269305.9",
"NM_000546.6"
],
"agr": "HGNC:11998",
"status": "Approved",
"omim_id": [
"191170"
],
"uuid": "22e519f0-ad02-4326-b78b-d972b5873187",
"lsdb": [
"IARC TP53 Mutation Database|http://www-p53.iarc.fr/",
"p53 UMD TP53 mutation database|http://p53.fr/",
"Database of Germline p53 Mutations|http://www.lf2.cuni.cz/projects/germline_mut_p53.htm",
"MUTP53LOAD, Mutant p53 Loss Of Activity Database|http://www.umd.be:2072/",
"LRG_321|http://ftp.ebi.ac.uk/pub/databases/lrgex/LRG_321.xml"
],
"name": "tumor protein p53",
"rgd_id": [
"RGD:3889"
],
"ucsc_id": "uc060aur.1",
"location": "17p13.1",
"cosmic": "TP53",
"uniprot_ids": [
"P04637"
],
"hgnc_id": "HGNC:11998",
"gencc": "HGNC:11998",
"alias_symbol": [
"p53",
"LFS1"
]
}
]
}
}Attribution: Source: HGNC, HUGO Gene Nomenclature Committee at EMBL-EBI (genenames.org), released under CC0. RRID:SCR_002827.
Licence: CC0 1.0 Public Domain Dedication. The HGNC License Agreement page (genenames.org/about/license) states: "The HUGO Gene Nomenclature Committee (HGNC) wants to ensure that our information is accessible to the public and free to use, for this reason all data is released under the Creative Commons Public Domain (CC0) License. This means that any form of reuse of the content is permitted." On attribution it adds: "Although stating the source is not mandatory, the HGNC recommends attribution (e.g. in publications, services or products) for any of its online services, databases or software as it helps us understand how our HGNC resource is used and secure funding for its ongoing development." Commercial use and redistribution are therefore both permitted; we credit HGNC anyway because they ask.
Ask with this source
A prompt for your agent that names this source and how to call it through the crw MCP.
Gene by alias name
Use HGNC (HUGO Gene Nomenclature Committee) (hgnc) from fastCRW Pergamon, capability "Gene by alias name" (gene-by-alias-name). You have a descriptive or disease name used informally for a gene and want the approved record. Example options: alias_name="Li-Fraumeni syndrome". Use the crw MCP tools: crw_find_data to confirm the source and its options, then crw_get_data with provider "hgnc" and capability "gene-by-alias-name". Tell me the credits used and cite the licence from the response. If the crw MCP tools are missing, install them with: npx -y crw-mcp install --api-key <your fastCRW API key>
Gene by alias symbol
Use HGNC (HUGO Gene Nomenclature Committee) (hgnc) from fastCRW Pergamon, capability "Gene by alias symbol" (gene-by-alias-symbol). You have an informal or literature symbol such as p53 and need the approved gene it refers to. Example options: alias_symbol=p53. Use the crw MCP tools: crw_find_data to confirm the source and its options, then crw_get_data with provider "hgnc" and capability "gene-by-alias-symbol". Tell me the credits used and cite the licence from the response. If the crw MCP tools are missing, install them with: npx -y crw-mcp install --api-key <your fastCRW API key>
Gene by CCDS ID
Use HGNC (HUGO Gene Nomenclature Committee) (hgnc) from fastCRW Pergamon, capability "Gene by CCDS ID" (gene-by-ccds-id). You hold a Consensus CDS identifier and want the gene whose coding sequence it describes. Example options: ccds_id=CCDS11453. Use the crw MCP tools: crw_find_data to confirm the source and its options, then crw_get_data with provider "hgnc" and capability "gene-by-ccds-id". Tell me the credits used and cite the licence from the response. If the crw MCP tools are missing, install them with: npx -y crw-mcp install --api-key <your fastCRW API key>
Gene by ENA/GenBank accession
Use HGNC (HUGO Gene Nomenclature Committee) (hgnc) from fastCRW Pergamon, capability "Gene by ENA/GenBank accession" (gene-by-ena-accession). You have an INSDC nucleotide accession from GenBank, ENA or DDBJ and want the gene HGNC links it to. Example options: ena=U14680. Use the crw MCP tools: crw_find_data to confirm the source and its options, then crw_get_data with provider "hgnc" and capability "gene-by-ena-accession". Tell me the credits used and cite the licence from the response. If the crw MCP tools are missing, install them with: npx -y crw-mcp install --api-key <your fastCRW API key>