Human Protein Atlas

Returns, per matching gene, the HPA antibody identifiers raised against the protein, their RRIDs, and the reliability scores for immunohistochemistry, mouse brain immunohistochemistry and immunofluorescence.

Returns, per matching gene, the RNA specificity category, distribution, Tau score and specific nTPM across immune cell types and across blood cell lineages, plus the measured plasma protein concentration in pg/L by immunoassay and by mass spectrometry.

Returns, per matching gene, the RNA expression value in nTPM for each of the 18 sorted human immune cell populations as separate numeric fields.

Returns, per matching gene, the RNA specificity category, distribution, Tau score and specific nTPM across human brain regions, the human single-nuclei brain specificity, and the equivalent regional measures for mouse and pig brain.

Returns, per matching gene, the RNA expression value in nTPM for each of the 13 human brain regions as separate numeric fields.

Returns, per matching gene, the single-nuclei RNA expression value in nCPM for each of the 34 human brain cell types and regional neuron populations as separate numeric fields.

Returns, per matching gene, the RNA specificity category, distribution, Tau specificity score and specific pTPM across TCGA cancer types.

Returns, per matching gene, the prognostic result for each of 31 cancer cohorts - 24 TCGA cohorts plus 7 independent validation cohorts - each giving the prognostic type, whether the gene is favourable, unfavourable or unprognostic, and the underlying p-value and expression cutoff.

Returns, per matching gene, the RNA specificity category, distribution, Tau score and specific nTPM across the HPA cancer cell line panel, plus the cell line expression cluster it belongs to.

Returns, per matching gene, the RNA expression value in nTPM in each of roughly 1,200 human cancer cell lines, named individually and grouped by cancer of origin.

Returns, per matching gene, the antibody staining level - not detected, low, medium or high - for each annotated cell type within each tissue, around 280 tissue and cell type pairs.

Returns, per matching gene, the deep visual proteomics protein intensity for each of the 27 profiled human cell types as separate numeric fields.

Runs an HPA search and returns only the columns you name, as an array of one JSON object per matching gene.

Returns, per matching gene, the UniProt biological process and molecular function keywords plus the protein existence evidence level as summarised by HPA, UniProt and neXtProt.

Returns, per matching gene, the co-expression cluster it belongs to in each HPA clustering: tissue, brain, blood, cell line and single cell, each named with its dominant tissue and biological theme.

Returns the complete Human Protein Atlas record for one gene in a single JSON object: symbol, synonyms, UniProt and Ensembl ids, chromosome position, protein classes, biological process and molecular function, disease involvement, antibodies and their reliability scores, subcellular locations, secretome annotation, and the RNA and protein expression summaries across tissue, brain, single cell type, blood, cell line and cancer.

Returns, per matching gene, the approved symbol, synonyms, Ensembl gene id, gene description, UniProt accessions, chromosome and base positions, HPA protein classes, disease involvement and the number of known protein interaction partners.

Runs an HPA search and returns the full entry - every field the single-gene record carries - for each matching gene as an array of JSON objects.

Returns, per matching gene, the HPA secretome annotation: where the protein is secreted to - blood, extracellular matrix, digestive system, brain and so on - and its annotated secretome function.

Returns, per matching gene, the single-cell RNA specificity category, distribution, Tau score and specific nCPM at both cell type and cell type group level, the cell types it is enriched in within each tissue, and the protein-level cell type specificity from deep visual proteomics.

Returns, per matching gene, the immunofluorescence subcellular locations split into main and additional locations, the IF reliability score, and whether the protein or its transcript shows cell cycle dependent variation.

Returns, per matching gene, the RNA tissue specificity category, distribution, Tau specificity score and the tissues with specific nTPM, alongside the same four measures at protein level from immunohistochemistry.

Returns, per matching gene, the antibody staining level - not detected, low, medium or high - scored by pathologists in each of the ~45 HPA tissues.

Returns, per matching gene, the mass-spectrometry protein intensity measured in each of the ~20 HPA tissues as separate numeric fields.

Returns, per matching gene, the consensus RNA expression value in nTPM for each of the ~50 HPA human tissues as separate numeric fields.